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KMID : 1140420170260040287
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Journal of Obesity & Metabolic Syndrome
2017 Volume.26 No. 4 p.287 ~ p.290
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Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women
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Lee Seong-Kyu
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Abstract
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Background: Monocyte chemoattractant protein-1 (MCP-1) is expressed in adipose tissue, macrophages, endothelial cells, and osteoblasts by parathyroid hormone administration. Circulating MCP-1 levels are positively correlated with the degree of obesity. However, whether circulating MCP-1 affects bone metabolism is unclear. Therefore, in this study, the association between circulating MCP-1 levels and lumbar bone mineral density (BMD) based on menopausal status was assessed.
Methods: We recruited 109 premenopausal and 46 postmenopausal Korean women and examined the association between circulating MCP-1 concentrations and various parameters including lumbar BMD based on menopausal status.
Results: A significant increase in body weight, abdominal circumference, body mass index, and MCP-1 levels (from 245.9±73.5 to 336.5±101.7 pg/mL) and significant decrease (from 0.992±0.114 to 0.772±0.113 g/cm2) in lumbar BMD were observed after menopause. However, circulating MCP-1 levels were not correlated with any parameters including lumbar BMD in premenopausal or postmenopausal women.
Conclusion: Circulating MCP-1 levels were not correlated with lumbar BMD regardless of menopausal status.
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KEYWORD
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Monocyte chemoattractant protein-1, Bone density, Women
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